Page 27 safety data sheet according to 19072006ec, article 31 printing date 05. Clear, colourless, sterile solution intended for parenteral administration to human beings. C15h21no2 a narcotic compound that is used medicinally as an analgesic and sedative explanation of pethidine hydrochloride. Dbl pethidine hydrochloride injection bp is available as a 50 mg1 ml, 75 mg1. By subcutaneous injection, or by intramuscular injection. It should be used only once and any residue discarded. Drug pethidine hcl 50mg1ml 1ml injection pethidine.
Enter synonyms, trade names or additional information found in section 1. Hcl component approximate percent by weight cas number rtecs number meperidine hydrochloride 1 505 ns5950000 nonhazardous ingredients include water for injection. Dbl pethidine hydrochloride injection bp pethidine. Analgesic, adjunct to anesthesia controlled substance schedule ii pregnancy risk category c action binds to and depresses opiate receptors in spinal cord and cns, altering perception of and response to pain availability injection. Astrazeneca pty ltd alma road, north ryde nsw 21 australia. What dbl pethidine hydrochloride injection bp is used for in some overseas countries, pethidine is called meperidine. This injection contains 79 mg sodium chloride in order to render. Each 1ml of solution contains 50mg of pethidine hydrochloride b. Dbl pethidine hydrochloride injection bp is a sterile, clear solution.
Dbl pethidine hydrochloride injection bp is a sterile, clear solution of pethidine hydrochloride bp and sodium hydroxide in water for injections bp. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Dbl pethidine hydrochloride injection bp pethidine peth. Pethidine has an analgesic potency approximately equal to onefifth that of morphine. Greece oel twa 10 ppm 25 mgm3 belgium oel twa hungary oel twa 25 mgm3 10 ppm 25 mgm3 version. The pethidine hcl, with cas registry number 55989098, has the systematic name of ethyl 1methyl4phenylpiperidine4carboxylate hydrochloride 1. Hydrogen chloride gas advice for firefighters wear self contained breathing apparatus for fire fighting if necessary. Pethidine hydrochloride 5 10 505 wash out mouth with water. No studies have been done in animals, and no wellcontrolled studies have been done in pregnant women.
Meperidine hydrochloride crm safety data sheet section 2. Toxicological information information on toxicological effects general information. Besides this, it is also called pethidine hydrochloride. If dose is less effective after a few if dose is less effective after a few weeks, do not increase dose without consulting health care professional. Empirical formula hill notation c 15 h 21 no 2 hcl. Meperidine hydrochloride injection, usp cii for use with pca hospira inc. It mainly acts on the cns and respiratory and git systems. The hazard classification and labelling section shows the hazards of a substance based on the standardised system of statements and pictograms established under the clp classification labelling and packaging regulation. A new method for the evaluation of analgesics is described. There is another drug, called naloxone, which can be used to reverse the effects of too much pethidine if. Pethidine hydrochloride british pharmacopoeia bp reference standard. Identification of the substancemixture and of the companyundertaking product name. Find out information about pethidine hydrochloride. Product name dbl pethidine hydrochloride injection bp 50 mgml.
Pethidine 1methyl4phenylpiperidine4carboxylic acid ethyl ester c15h21no2 hcl. The drug is well absorbed orally but more than 50% undergoes first pass metabolism. Pethidine hydrochloride may be used as an analgesic for the relief of moderate to severe pain including. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Dbl pethidine hydrochloride injection bp is available as a sterile, isotonic 50 mg 10 ml solution.
The name of your medicine is pethidine hydrochloride 50mgml solution for injection but will be referred to as pethidine injection throughout the remainder of this lea. C15h21no2 a narcotic compound that is used medicinally as an analgesic and sedative explanation of. The substance identity section is calculated from substance identification information from all echa databases. Pethidine, also known as meperidine and sold under the brand name demerol among others. Any reference in these archives to astrazeneca products or their uses may not reflect current medical knowledge and should not be used as a source of information on the present product label, efficacy data or safety data. Meperidine hydrochloride pethidine hydrochloride sigma. Pethidine hydrochloride injection 50mgml 5874 50 each ml. Indications and dosages moderate to severe pain adults. Chemical product and company identification product name. Should new zealand continue signing up to the pethidine protocol. Pethidine hydrochloride has been found to possess one fifth to one sixth of the analgesic activity of morphine hydrochloride against mild pain stimuli, but to be ineffective against severe pain. Do not stop using pethidine, or lower the dosage, without checking with your doctor or pharmacist.
Pethidine injection bp pethidine hydrochloride drug. Cefepime hydrochloride, usp for injection for intravenous or intramuscular use to reduce the development of drugresistant bacteria and maintain the effectiveness of maxipime and other antibacterial drugs, maxipime should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. The information included in this section describes the potential hazards of the individual ingredients. Page 17 safety data sheet according to 19072006ec, article 31 printing date 05. Pethidine hydrochloride drug bnfc content published by nice. Pethidine tablets, pethidine tablets manufacturer in india. Chronic pethidine treatment induces histone h3 acetylation in rat brain. Closed cup as in any fire, wear selfcontained breathing apparatus pressuredemand niosh approved or. The substance identifiers displayed in the infocard are the best available substance name, ec number, cas number andor the molecular and structural formulas. Remove victim to fresh air and keep at rest in a position comfortable for breathing. Important notice for users you are about to access astrazeneca historic archive material. Pethidine is most commonly used to relieve severe pain. If you have been using pethidine for more than two weeks, you may experience unpleasant feelings if you stop it suddenly.
What you need to know before you are given pethidine injection 3. Cefepime is an antibacterial agent belonging to the cephalosporin class of antibacterials with. Stop if the exposed person feels sick as vomiting may be. Pethidine meperidine is a synthetic opioid which primarily acts on m opioid receptors. For intravenous administration the dosage should be decreased and the injection administered very slowly as a dilute solution. Pethidine hydrochloride injection staff characteristics registered midwife clinical details clinical situation for which medicine is to be used for the relief of pain in labour either alone or in combination with other specified drugs.
Pethidine hydrochloride drug bnf content published by. Pethidine 50mg1ml solution for injection ampoules martindale pharmaceuticals ltd schedule 2 cd. Cefepime hydrochloride, usp for injection for intravenous or intramuscular use. Bp 25, 50,100 mgml 1 ml ampoules containing 25 mg pethidine hydrochloride. Do not use dbl pethidine hydrochloride injection bp to treat any other complaints unless your doctor or pharmacist tells you to. Ld50 lethal dose, 50 percent kill route of exposure. Closed cup as in any fire, wear selfcontained breathing apparatus pressuredemand niosh approved or equivalent, and full protective gear to prevent contact with skin and eyes. And the chemical formula of this chemical is c 15 h 22 clno 2.
Pethidine hydrochloride drug bnf content published by nice. Conforms to hazcom 2012united states safety data sheet. The free base conversion ratio for salts includes 0. Identification of the substancemixture and of the companyundertaking product identifier pethidine solution details of the supplier of the safety data sheet po box 1.
The name of your medicine is pethidine hydrochloride 50mgml solution for injection but will be referred to as pethidine injection throughout the remainder of this leaflet. Pethidine doses should be carefully worked out, so problems with overdosage are unlikely. Mar 19, 2019 each 1ml of solution contains 50mg of pethidine hydrochloride b. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Name of drug classification alternate names narcotic. Pethidine hydrochloride injection 50mgml 5874 50 each ml contains pethidine hydrochloride 50mg ethylimethyl4phenylisonipecotate hydrochloride 1860, 1. Pethidine hydrochloride medicinal forms bnf content. Pethidine is a pain killer that belongs to a group of medicines called opioid analgesics. Pethidine is an analgesic or painreliever given to women to ease the pains labour. Hazardous ingredients present at less than 1% may include sodium hydroxide andor hydrochloric acid which are added for ph adjustment. Pethidine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.
By the use of this method, comparison of morphine, diacetylmorphine, codeine and pethidine hydrochlorides has been made. Pethidine hydrochloride injection is a clear and colourless sterile solution in clear glass ampoules. Meperidine is not recommended as a first choice analgesic by the american pain society and ismp 2007. Pethidine hcl is an opioid analgesic, prescribed for moderate to severe pain, for example labor pain, before and during a surgical operation.
What pethidine injection is and what it is used for 2. Meperidine hydrochloride pethidine hydrochloride sigmaaldrich. Pethidine hydrochloride drug bnfc content published by. Available forms available by prescription only injection. Firstaid measures description of first aid measures inhalation. Pethidine hydrochloride british pharmacopoeia bp reference. Pethidine hydrochloride substance information echa. The clp regulation makes sure that the hazards presented by chemicals are clearly communicated to. Dissolve the above product in ether, pass hydrogen chloride dry through the solution, and recrystallize the resulting salt from acetone, mp. Pethidine injection bp contains no antimicrobial agent. Pethidine hydrochloride may be administered by subcutaneous, intramuscular or slow intravenous injection.
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